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This work was supported by the Research and Evaluation of the National Major Science and Technology Projects of China (2018ZX10722301) and Beijing Municipal Health Commission High Level Public Health Talent Construction Project (Discipline Leader 01-11)

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Studies have shown that FIN56 can significantly reduce the survival rate of GBM cells (such as LN229 and U118 cells) by inducing ferroptosis, increasing lysosomal membrane permeability, inhibiting cell proliferation, and causing cell cycle arrest

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Acute Withdrawal Phase (2 to 8+ weeks) This is the most symptomatic part of withdrawal