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During aging, T cells develop genomic instability due to decreased DNA repair capacity, manifesting as reduced proliferative potential and weakened effector functions, ultimately leading to immune senescence (81,82)

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[3] Both active and latent TB Intravenous drug users with Mantoux test above 10 mm HIV-positive people with Mantoux test above 5 mm Those who had close contact with TB patient and have Mantoux test above 5 mm As a preventative measure for those with pulmonary silicosis or fibrotic pulmonary lesions from recovered TB Isoniazid can be used alone or in combination with Rifampin for treatment of latent tuberculosis, or as part of a four-drug regimen

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