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Mice with the NLGN3-R451C mutation exhibit social deficits and behavioral problems, with increased excitatory synaptic transmission in the CA1 region of the hippocampus and enhanced inhibitory synaptic transmission in the 2/3 layers of the somatosensory cortex (86).Enhanced inhibitory synaptic transmission in Purkinje cells is manifested as an increase in the amplitude of mIPSCs, with no significant change in frequency (87)

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Finally, we tested the impact of chemical inhibition of glutathione reductase and thioredoxin reductase using 1,3-bis-(2-chlorethyl)-l-nitroso-urea (BCNU) and auranofin, respectively ( Figure 7 HJ )