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5.2.2 Limitations due to the disease The pathophysiology of mutations or mechanisms underlying the neuronal pathology of mitochondrial diseases is still unknown in most patients, which makes it difficult to interpret the mitochondrial or neural readout in pharmacological screenings

These treatments are also linked to a new cadre of side effects, termed immune-related adverse events (irAEs)

Grou, C

CBD can also indirectly influence cellular activity by altering the release of neurotransmitters or cytokines from neighbouring cells, leading to non-cell autonomous effects

and finally employs an endosomal enzyme, cathepsin L (CTSL) for fusogenic release of its viral genome