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Optical Rotation, Specific Rotation 781S Sample solution: 40 mg/mL in water Acceptance criteria: 15.5 to 17.5 , at 20 ASSAY Procedure Sample: 500 mg of glutathione previously dried Titrimetric system (See Titrimetry 541 .) Mode: Direct titration Titrant: 0.1 N iodine VS Endpoint detection: Visual Blank: 50 mL of metaphosphoric acid (1 in 50) Analysis: Dissolve the Sample in 50 mL of metaphosphoric acid (1 in 50) and titrate with the Titrant

5559, Louisville, Kentucky: Westminster John Knox Press, ISBN 978-0-664-25017-1

For this reason, First-in-Human trials are not only a procedural milestone in drug development

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