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doi:10.1016/j.juro.2012.03.131

Some practitioners implement cycling approaches (such as 12 weeks on, 4-8 weeks off), though no published research directly compares continuous versus cycled protocols

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An 8-week randomized double-blind trial compared GHK-Cu in a nano-lipid carrier against Matrixyl 3000 and found a 55.8% reduction in wrinkle volume versus control serum, along with a 32.8% reduction in wrinkle depth