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That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route

When these compounds are put together into a solution that is injected into the bloodstream, it enters the body without any possibility of facing dilution or being inefficiently absorbed into the gut

The Be(2)-C cell line was selected due to its similar response profile as spheroids and delayed response to treatment compared to both MNA NB cell lines IMR-5/75 and IMR-32