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Compounds spanning 100-fold IC50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

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Therefore, CD39 may not be the only in vivo immune system switch that triggers ADO-mediated immunosuppression ( Under physiological conditions, the extracellular breakdown of ATP follows the conventional ATP/ADP/AMP/ADO adenosinergic pathway

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