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Other limitations include the fact that the in vitro granuloma model used is not an exact replication of in vivo granulomas which have a more complex and dynamic environment containing other cells like fibroblasts, collagen matrix, and other white blood cells

5A, Additional file 1: Dataset S1), especially at the intermediate infection stage (3 DPI), the suspected mostly important infection stage for P

Thirdly, they are manufactured using recombinant methods, resulting in high patient costs

80 Tu et al demonstrated that these vesicles modulate key signaling pathways, including NF-B, to inhibit inflammationoxidation cross-amplification and significantly enhance wound repair