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In the adult liver, LSECs exhibit distinct zonal markers 54 , which was recreated in the organoids where the endothelial structures acquire increasing CD54 + expression in proximity to the hepatocyte layer, which suggests that endothelial cell specialization is potentially a product of the niche (Fig

For clarification, oral administration of glucocorticoids also includes oromucosal, buccal, gingival and sublingual routes