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Reported Adverse Effects Reported adverse effects from online forums cited in a 2025 systematic review (PMC12313605) included: Anxiety and panic attacks Depression and anhedonia Insomnia Heart palpitations Fatigue and weakness Loss of appetite These anecdotal reports cannot be verified as directly caused by BPC-157 versus contamination, incorrect dosing, or concurrent conditions, but they raise concerns that the peptide might paradoxically worsen mental health in some individuals

2000 Apr;62(4):253-9

This term was used in adults, and it would be inappropriate to use this nomenclature for very carefully categorized pediatric LT recipients who fulfill criteria of AIH based on IAIHG scoring [213]

Moreover, some single nucleotide polymorphisms (SNPs) in the PPARGC1A gene for PGC-1 are associated with increased risk of MASH development in both adults and children