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The Chelate trial enrolled 53 clinically stable WD patients on maintenance D-penicillamine (DPA) (2)

Astrocytic reactivity reflects activation of complex molecularly defined programmes which define remodelling of biochemical, morphological, metabolic, and physiological properties of astroglia leading to an upregulation or loss of homoeostatic cascades, or in gain of new protective or regenerative functions

We finally performed stratified analysis, finding that LPD to be especially beneficial in terms of high metabolomic response for PSC patients with UC (but not PSC patients with CD, or PSC alone), which is consistent with the clinical response

(17) Irritable Bowel Syndrome (IBS) Clinical trials have found a link between Irritable Bowel Syndrome (IBS), oxidative stress and glutathione

Caeque T, Baron L, Mller S, Carmona A, Colombeau L, Versini A, et al