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Montalban X, Wallace D, Genovese MC, Tomic D, Parsons-Rich D, Le Bolay C, et al

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However, even in glycolytic tumors, mitochondria remain essential for various metabolic processes, including the generation of ATP and the regulation of metabolic intermediates ( 2.2.3 Interactions between mitophagy and the tumor microenvironment TME is a complex milieu that significantly influences tumor progression and response to therapy ( The ability of tumor cells to adapt their mitochondrial function through autophagy allows them to thrive in the immunosuppressive environment typical of many tumors, further complicating treatment strategies

Predicting pharmacodynamic effects through early drug discovery with artificial intelligence-physiologically based pharmacokinetic (AI-PBPK) modelling