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J Cardiovasc Pharmacol (1994) 24(4):64854

In some antibody constructs, the heavy chain CDR3 appears to constitute the major area of contact between the antigen and the antibody

Nonetheless, in both those studies, the number of participants was quite low

And finally, subunit vaccines can constitute viral proteins incorporated in synthetic nanomaterials, protein cages and VLPs, which serve as adjuvants and/or delivery vehicles, in addition to conferring other benefits inherent to each nanocarrier platform 55,56,57