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They then isolated the virus from the hearts of the mice from both groups and found that the coxsackievirus from the deficient animals hearts had become mostly virulent7

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290 Besides, ROS directly activate ASK1 through homo-oligomerization and autophosphorylation at Thr838 or hetero-oligomerization with ASK2, where ASK2 phosphorylates Thr838 of ASK1 after its own autophosphorylation at Thr806 291 (Table 1, Fig