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Regulatory concerns : BPC-157 is not approved by health authorities and is explicitly banned in competitive sports

Vazzquez-Roque and coworkers conducted a 4-week RCT of gluten-free diet in 23 IBS-D patients who were further subgrouped according to their HLA genotype (12 HLA-DQ2/8-negative and 11 HLA-DQ2/8positive), with 22 patients in the control group on gluten-containing diet

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Quality checks were performed using the 2100 BioAnalyzer (Agilent Techologies, Santa Clara, CA, USA), followed by library preparation with the NEBNext Ultra II DNA Library Prep Kit (Illumina, San Diego, CA, USA)

Initial studies demonstrated that although mature erythrocytes contain procaspase-3 and procaspase-8, they are devoid of the mitochondrial apoptotic machinery, e.g., APAF-1, cytochrome c, and caspases-2, -6, -7, and -9 [22, 23]