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The loss of the cation in the endoplasmic reticulum (ER) and consequent increase in the cytoplasm and mitochondrial matrix of the hepatocyte leads to the creation of reactive oxygen species (ROS) that causes mutations in nuclear and mitochondrial DNA (mtDNA), thus activating proliferative genes and inhibiting oncosuppressor genes [138]

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Moreover, nanogels could also be functionalized with targeting ligands to increase their specificity for dopaminergic neurons

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95% CI, 0.77-1.02) at 1 year in the GLP-1RA group

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2007 Jun;67(11):555360

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2-[(Cyclopentylcarbonyl)amino]-N-(2,4,6-trimethylphenyl)-6-benzothiazolcarboxamid

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