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The American Academy of Allergy, Asthma & Immunology distinguishes a normal local reaction (redness or itching only at the injection point) from a hypersensitivity reaction

33,34 The number of young individuals diagnosed with T2DM has been increasing

Variants like C677T and A1298C can reduce enzyme activity

Follow-up appointments every 4-12 weeks are essential for dose adjustments, with most patients reaching their optimal dose within 16-20 weeks of starting treatment