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An increase in absolute count of intermediate monocytes in TI calves may indicate stimulation of the immune system prior to data collection at 4 months of age, as treatment of classical monocytes in vitro with IFN resulted in expansion of the intermediate monocyte population [46]

Treatment with melatonin could restore the reduction of mitochondrial membrane potential and decrease the levels of caspase-3 and PARP, thereby ameliorating apoptosis in chondrocytes exposed to H 2 O 2 (144) ( Figure 4 )

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