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CJC+DAC carries higher risk of these effects due to the prolonged GH elevation compared to no-DAC

doi: 10.1002/med.21565 564 LiuKZhouRWangBMiMT

Whether this hypothesis is correct or whether accessible disulfides (e.g., within an extended loop or a flexible N- or C-terminus) circumvent such steric limitations remains to be analyzed

Because of the pentose phosphate pathway bottleneck and the lack of G6PDH enzyme, the body cannot quickly synthesize the D-Ribose needed to salvage and rebuild the lost ATP