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Outliers were removed from control data after identification with ROUT Q = 0.5% (number of outliers removed: NAD + /NADH ratio n = 2, NADP + /NADPH ratio n = 11 and GSH/SSG ratio n = 6, no outliers were identified for individual metabolites)

Paradoxically, in early ischemia, lactate overabundance fuels a pro-inflammatory M1-dominant milieu [153]

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GluRs are expressed on the cell surface, therefore, the accumulation of extracellular glutamate could induce the activation of surrounding cancer and immune cells increasing cell proliferation or anti-tumor response