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These multiple pathologies can be explained by the fact that HNE is a potent modulator of numerous cell processes such as oxidative stress signaling, cell proliferation, transformation or cell death

These findings suggest that Nrf2 exerts a pivotal function in counteracting inherent oxidative stress throughout the pathological process of PD, thereby further supporting its therapeutic potential

It consists of your liver, interstitium, and immune system

Promising strategies include repurposed antidiabetic drugs (e.g., SGLT-2 inhibitors, GLP-1 receptor agonists), microbiome-targeted therapies (e.g., fecal microbiota transplantation), and novel immunomodulatory agents