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This may also be a consequence of underlying assumptions of medium homogeneity underlying conventional attenuation-based analysis, even after accounting for overlying tissue, and high sensitivity of attenuation-based outcomes to shadowing 30, 67

Glossary 4EBP1 Eukaryotic Translation Initiation Factor 4E Binding Protein 1 AIP Aryl Hydrocarbon Receptor Interacting Protein AKT AKT Serine/Threonine Kinase AP-1 Activator protein 1 ATF-2 Activating Transcription Factor 2 Bcl-X L Bcl2 Like 1 BMI1 B Lymphoma Mo-MLV Insertion Region 1 Homolog Cas9 CRISPR associated protein 9 CCNA2 Cyclin A2 CDK4 Cyclin Dependent Kinase 4 CRC colorectal cancer CREB cAMP response element-binding protein CRISPR Clustered Regularly Interspaced Short Palindromic Repeats DLC-1 DLC1 Rho GTPase Activating Protein E2F1 E2F Transcription Factor 1 eIF4A3 Eukaryotic Translation Initiation Factor 4A3 EMT epithelial-to-mesenchymal transition ERK extracellular signal-regulated kinase FSCN1 Fascin Actin-Bundling Protein 1 GATA4 GATA Binding Protein 4 GH growth hormone GHR growth hormone receptor GHRH Growth Hormone Releasing Hormone GRB2 Growth Factor Receptor Bound Protein 2 GSK3 / Glycogen Synthase Kinase 3 Alpha and Beta HMGA1 High Mobility Group AT-Hook 1 HMGA2 High Mobility Group AT-Hook 2 IGF1 Insulin Like Growth Factor 1 IGF2 Insulin Like Growth Factor 2 IGF1R Insulin Like Growth Factor 1 Receptor IGF2R Insulin Like Growth Factor 2 Receptor IGF2BP3 Insulin Like Growth Factor 2 mRNA Binding Protein 3 IGFBP Insulin Like Growth Factor Binding Protein IRS Insulin Receptor Substrate JAK Janus Kinase JNK c-Jun N-terminal kinase KIT KIT Proto-Oncogene, Receptor Tyrosine Kinase KRAS KRAS Proto-Oncogene, GTPase lncRNA long non-coding RNA MAPK Mitogen-Activated Protein Kinase MEK1/2 Mitogen-Activated Protein Kinase 1/2 MEN1 Menin 1 miRNA microRNA MMP Matrix Metallopeptidase mTOR mammalian target of rapamycin mTORC1 mTOR Complex 1 NF-Kb nuclear factor kappa-light-chain-enhancer of activated B cells p27 protein 27, encoded by CDKN1B Cyclin Dependent Kinase Inhibitor 1B p38 protein 38 mitogen-activated protein kinase p57 protein 57, encoded by CDKN1C Cyclin Dependent Kinase Inhibitor 1C p70 protein 70 S6 Kinase Protein p90 protein 90 ribosomal S6 kinase PDCD4 Programmed Cell Death 4 PI3K phosphoinositide 3-kinase PIK3R1 Phosphoinositide-3-Kinase Regulatory Subunit 1 pitNETs Pituitary neuroendocrine tumors PLAG1 PLAG1 Zinc Finger PLAGL2 PLAG1 Like Zinc Finger 2 PRLT prolactin PTEN Phosphatase And Tensin Homolog Pttg1 PTTG1 Regulator Of Sister Chromatid Separation, Securin Raf1 Raf-1 Proto-Oncogene, Serine/Threonine Kinase RAS rat sarcoma protein RB retinoblastoma RUNX2 RUNX Family Transcription Factor 2 SHC Src Homology 2 Domain-Containing protein Smad7 SMAD Family Member 7 SOS Son of sevenless Ras/Rac Guanine Nucleotide Exchange Factor SSAs Somatostatin analogues SSTR2 Somatostatin Receptor 2 STAT Signal Transducer And Activator Of Transcription TGCA The Cancer Genome Atlas TGF Transforming Growth Factor Beta TIMP3 Metallopeptidase Inhibitor 3 UTR untranslated region VEGF Vascular Endothelial Growth Factor YB-1 Y-box binding protein 1 Wnt wingless integrated References 1 BoguszewskiCLBoguszewskiMCKopchickJJ

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In this disease, the failure to upregulate CHAC1 is detrimental