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Several studies have demonstrated that hyperactivation of the renin-angiotensin system in the SN and striatum may exacerbate oxidative stress by stimulating the NADPH-oxidase activity, and the microglial inflammatory response (Garrido-Gil et al., 2012)

The most plausible threat from bias is that the COVID-19 pandemic resulted in a systematic change to the methods (e.g., to the sampling strategy, response rates or to the data collection methods) affecting particularly the 2020/21 and 2021/22 surveys