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ANG1005, a novel brain-penetrant taxane derivative, for the treatment of recurrent brain metastases and leptomeningeal carcinomatosis from breast cancer [abstract]

Eddie walks every patient through their first injection in person

The significant increase in fissures observed in the PCPA-induced insomnia model group suggests that sleep disturbances may lead to notable changes in brain tissue morphology (Figures 8A,B)

In Cycle 1, CRS events occurred in 6% of patients after the 0.16 mg dose (Cycle 1, day 1), 12% after the 0.8 mg dose (Cycle 1, day 8), 43% after the first 48 mg dose (Cycle 1, day 15), and 5% after the next 48 mg dose (Cycle 1, day 22)