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Yang B, Xi M, Cui S, et al

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[Abstract]2020 Nov;94(11):3799-3817

After a stable infection was established (68 weeks), mice were treated with different antibiotic triple therapies by oral gavage twice a day for 7 days: metronidazole or Metro-P3 (14.2 mg kg 1 day 1 ) or Metro-P3 (0.02 14.2 mg kg 1 day 1 = 0.30 mg kg 1 day 1 ) or MF-01 (0.02 14.2 mg kg 1 day 1 = 0.30 mg kg 1 day 1 ) or metronidazole (0.02 14.2 mg kg 1 day 1 = 0.30 mg kg 1 day 1 ) with clarithromycin (7.15 mg kg 1 day 1 ) or clarithromycin only (control group, 7.15 mg kg 1 day 1 )

Intratracheal NCOA4 siRNA injection in WT mice reduced lipid peroxidation and also reduced CS induced cell death in airway, partially supporting the notion that NCOA4-mediated ferritinophagy has a crucial role in ferroptosis (Supplementary Fig