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Importantly, we also found that Mn accumulates in slc39a11 mutant zebrafish, as well as in the serum of both global Slc39a11 knockout and hepatocyte-specific Slc39a11 knockout mice, suggesting that this metal transporter regulates systemic Mn levels 54

The conditional knockout of SLC7A11 in the pancreas delays KRAS G12D TP53 R172H -induced pancreatic cancer growth, partly through cysteine depletion-induced ferroptosis

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Dilda, Tumour Metabolism Group, Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

doi: 10.1111/ijfs.16096