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Although most studies investigating the OLG life cycle have been conducted in animal models, there is significant evidence to suggest that DNA methyltransferases and DNA methylation are dynamic in the processes of OPC specification, survival, proliferation, differentiation, and myelination [68, 70, 83, 104, 105]

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Ridker currently serves as Trial Chairman and Principal Investigator of two multi-national, randomized, placebo-controlled clinical trials designed to address whether reducing inflammation can reduce cardiovascular event rates