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The histidine residues provide a tertiary structural interaction with the two domains of PrP and copper, that is also protective in function due to involvement of the conserved central region of the protein (Roseman et al., 2020)

CD11b, Integrin alpha M

Scientific references (1) McPherson RA

For example, the limited endogenous H 2 O 2 and elevated GSH levels in tumor cells reduce the effectiveness of the iron-based nanocarrier 10-hydroxycamptothecin (HCPT) in inducing ferroptosis