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Eventually, the rigid, folded, stable conformation of protein will unfold

IBAT inhibitors have shown efficacy to treat cholestatic pruritus, including in PBC, but concurrent use of an IBAT inhibitor and obeticholic acid (OCA) is not well studied

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Compared with the NC group, animal experiments found that the serum aspartate transaminase (AST), alanine transaminase (ALT), total cholesterol (TC), and TG were increased in the HF group, and the level of liver TG was also increased

This will include targeted investment at priority sites as well as investigations and improvement work on parts of the sewer network to reduce infiltration