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The dose of fentanyl we chose for this study (75 g/kg, IV) elicited a robust decrease in minute ventilation (approximately 50% over a period of at least 60 min) and so represents a substantial level of ventilatory impairment by which to examine the effects of the 100 mol/kg dose of GSHee

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Clin Pharmacol Ther 48(4):381389 Bramness JG, Skurtveit S, Gulliksen M, Breilid H, Steen VM, Morland J (2005) The CYP2C19 genotype and the use of oral contraceptives influence the pharmacokinetics of carisoprodol in healthy human subjects