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It involves the decomposition of H 2 O 2 into water and monodehydroascorbate (MDHA) by ascorbate peroxidase (APX), the reduction of MDHA to ascorbate (AsA) or its disproportionation to dehydroascorbate (DHA) by MDHA reductase (MDHAR), and the reduction of DHA back to AsA by dehydroascorbate reductase (DHAR) using glutathione (GSH)

These HEVs increase effector T cell infiltration and activity by activating lymphotoxin receptor (LTR) signaling, thereby improving therapeutic efficacy [85]

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doi:10.1016/j.jad.2006.08.022 [cited 2021 Nov 24] 36

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