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J Exp Clin Cancer Res (2014) 33(1):0140092

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Although the heavy subunit by itself can catalyze the formation of L--glutamyl-L-cysteine, binding with the modifier subunit enhances the enzyme activity by lowering the Km for glutamate and ATP, and increasing the Ki for GSH inhibition

[DOI] [PMC free article] [PubMed] [Google Scholar] [47].Agarwal R, Hennings L, Rafferty TM, Letzig LG, McCullough S, James LP, MacMillan-Crow LA, Hinson JA