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Al Ani A, Qureshi PAAA, Bollineni VR Cureus 2023

Traumatic injury to your lower back Falls, motor vehicle accidents or a direct hit to your lower back can cause fractures of your spine or soft tissue injuries, which in turn leads to inflammation, irritation and compression of the sciatic nerve

Patients can have mild side effects, which are temporary and mild, such as nausea

Topline results announced in December 2025 were positive, showing that patients who switched from injectables to oral orforglipron maintained their weight loss

The counter argument is that sometimes the bowel becomes sensitive because of diarrhea that it is constantly in spasm