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The disease mechanism centers on disrupted equilibrium between tissue breakdown and rebuilding within the disc, causing deterioration of the extracellular matrix, depletion of proteoglycans and hydration, decreased disc height, and compromised mechanical stability

CAT specifically downregulated alanine aspartate and glutamate metabolism, and biotin metabolism among several highlighted pathways

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doi: 10.1016/j.jfda.2019.01.002 210

And another reason that occurs is because when you breathe through your mouth, it's far easier to engage in shallow chest breathing