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This creates a well-documented vicious cycle: stress increases histamine release, histamine amplifies nervous system reactivity (histamine H3 receptors modulate neurotransmitter release, and elevated brain histamine disrupts sleep, worsens anxiety, and heightens stress perception), which in turn drives more stress and further mast cell activation

These actions play a crucial role in maintaining immune homeostasis and preventing excessive inflammation, which can damage tissues and organs

STAT3 then translocates to the nucleus to activate the expression of pro-inflammatory genes (Moshapa et al., 2019)

Catalyst-wise, we tend to stick with the Sorcerer's Staff the assassin starts with as it's nice and light and provides a decent spell buff when upgraded