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R 3 is selected from the group consisting of H and CH 3 , R4 is selected form the group consisting of 6-8C alkyl, benzyl, naphthyl and a therapeutically active compound, and R5 is selected from the group consisting of H, phenyl, CH 3 and CH 2 phenyl or a pharmaceutically acceptable salt thereof

The peptide also has some anticoagulating properties on its own: It binds to platelets in the blood, enabling action at the clotting site. Without an added bonding agent, heparin applies its anti-clotting properties indiscriminately, not just at blood clot sites, and clears quickly, its half-life only 60 to 90 minutes

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A.LiebermanG.ChopraR.DorseyK.ChopraV.et al

All of the participants had recurrent or metastatic breast cancer that was progressing despite two or more chemotherapy regimens directed specifically at HER2