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Ninety-seven percent had ascites, 64% had hepatic encephalopathy, 9% had portal hypertensive bleeding, and 58% met the NACSELD definition of ACLF

The schedule mirrors the clinical-trial protocols that drove significant weight loss up to 24% at 48 weeks on 12 mg weekly [2] while holding gastrointestinal effects down through gradual escalation [1] [4]