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Perioperative supplementation of EPA reduces immunosuppression induced by postoperative chemoradiation therapy in patients with esophageal cancer

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Mazieres J, Drilon A, Lusque A, Mhanna L, Cortot AB, Mezquita L, Thai AA, Mascaux C, Couraud S, Veillon R, et al

The expression level of pyruvate dehydrogenase (encoding by aceE ), which catalyzes the reaction from pyruvate to the formation of acetyl-CoA, was only 0.13-fold in MG12345

With respect to Rybelsus it is furthermore noted that it must be taken on an empty stomach (after overnight fasting) followed by additional 30 minutes without food intake or high water intake