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Meanwhile, insulin deficiency or defects in the insulin/Akt2 pathway mediate downregulation of endothelial ATP7A, impairing the binding of Cu to SOD3 in the trans-Golgi network (91)

336,337 Failure of glutamate homoeostasis in epilepsy reflects significant down-regulation of astrocytic glutamate transporters and glutamine synthetase, the two principal components of the glutamate (GABA)-glutamine shuttle