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These findings align with preclinical data showing that circadian disruption enhances TNBC tumor growth and impairs the time-dependent efficacy of cisplatin therapy, suggesting that both intact circadian signaling and melatonin rhythms are crucial for optimizing chemotherapeutic outcomes 58

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11, 2005, at Lambeau Field in Green Bay, Wisconsin.Jonathan Daniel, Getty ImagesGreen Packers quarterback Aaron Rodgers stands on the sidelines during a preseason game against the New England Patriots on Friday, Aug

However, research protocols often compare systemic (subcutaneous) administration with localized administration to determine if one is more effective for a specific injury model.