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Description

Outcome measures include biomechanical testing (load to failure, stiffness), histological scoring (collagen organization, fibroblast density), and functional assessment (gait analysis, range of motion)

To further validate the hypothesis that Quercetin-preconditioned MSC-derived exosomes (Que-Exo) synergistically enhance chondroprotection and exert anti-inflammatory effects, we performed Western blot analysis to assess the expression of inflammatory markers (iNOS, TNF-) and catabolic enzymes (MMP-3, MMP-13) in IL-1-stimulated chondrocytes

Among them, PMM catalyzes the conversion of mannose-6-phosphate (M6P) to mannose-1-phosphate (M1P) (Zhang et al., 2018)

and O.P

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