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Under the trial-product estimand (assuming participants stayed on treatment), the reduction was 22.7%

Surfaces and agitation Vials, stoppers, filters, particles, foam, and interfaces can affect physical stability

Senolytic compounds can act by inhibiting these proteins, promoting cell death in senescent cells.51,52 For instance, navitoclax (ABT-263), venetoclax, and ABT-737 are BCL-2 inhibitors that disrupt pro-survival signaling, leading to senescent cell death

Measurement checklist: primary endpoint (defined), secondary endpoints (histology, angiogenesis markers), timepoints, and statistical plan for smalln studies

This designation is in compliance with regulatory frameworks for research compound distribution and use