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Expanding evidence exists on the dependence of these processes on cysteine and its metabolism, as cysteine contributes to the generation of hydrogen sulphide (H 2 S) 15,16,17,18,19,20 and glutathione (GSH) 21,22,23

Abstract Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US, and decades of intense study of its pathogenesis resulted in the development of the antidote N -acetylcysteine, which facilitates scavenging of the reactive metabolite and is the only treatment in clinical use

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