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Fertil Steril (2014) 102(6):157683.e4

On the other hand, disruption of ZC3H7A , MCM8 or MCM9 were identified to drive GSC sensitivity to TMZ following a negative selection CRISPR KO screen in response to sublethal doses of TMZ [64]

They can cause temporary symptom relief, but do not affect the progression of damage to bone and cartilage

While this effect could potentially be explained by the propensity for EGFR to co-amplify with CHCHD2, the amplification of EGFR was not solely associated with a decreased patient survival (Fig