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Treatment Resistant Schizophrenia: Effects of Smoking on Clozapine and Health Page 2 of 3 Psychiatry Advisor Nicotine normalizes brain deficits key to schizophrenia CU Boulder Today University of Colorado Boulder Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first episode schizophrenia Schizophrenia The Intrinsic Receptor Deficit In the general population, chronic smoking leads to an upregulation of 42 nicotinic receptors. In schizophrenia, this compensatory upregulation is impaired. This suggests an intrinsic defect in the Smoking 'could cause schizophrenia', say scientists The Independent The Independent

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