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Environment dictates dependence on mitochondrial complex I for NAD + and aspartate production and determines cancer cell sensitivity to metformin

K., Hambleton, I

To exclude the effects of these metabolic intermediates on pyroptosis, we then pretreated hepatocytes with L-methionine (L-Met) or tetrahydrofolic acid (THF) and found neither can block GSDME-mediated pyroptosis (Supplementary Fig