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Abnormal NLRP3 inflammasome activation and excessive IL-1 secretion is the major reason of CAPS, and has been demonstrated in three clinical subtypes: neonatal-onset multisystem inflammatory disease (NOMID), Muckle-Wells syndrome (MWS), and familial cold autoinflammatory syndrome (FCAS)

Because they possess both polar and nonpolar regions, molecules of bile acids are able to solubilize biliary lipids

Biomedicines (2021) 9:1817

In one study, the cell-to-cell interaction between HUVEC and QG90 cell, a tumor cell line derived from human small cell carcinoma of the lung expressing sialyl-LewisX antigen was studied, and it was found that IL-1 was able to induce the attachment of cancer cells to HUVEC

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