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As a surgeon, that brings me great joy. Dr

The activation of NRF2 by this mechanism enhances the transcription of genes involved in antioxidant defense and cystine/glutamate exchange, particularly those coding for components of the xCT antiporter (such as SLC7A11), which imports cystine in exchange for glutamate

Among them, DNL201, a CNS-penetrant LRRK2 inhibitor, has been shown in preclinical studies to effectively reduce LRRK2 activity and restore lysosomal function

De novo biosynthesis of GSH is controlled by the rate-limiting enzyme, glutamate-cysteine ligase (GCL, also known as -glutamylcysteine synthetase, -GCS) which consists of a catalytic (heavy) ( -GCSh) and a regulatory (light) subunit ( -GCSl)