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In addition, Okabayashi et al

IGF-1 is broadly implicated in cell proliferation, extracellular matrix organization, angiogenic signaling, and tissue regeneration, which is why GH-axis stimulation is frequently studied in relation to repair processes

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The SBR was calculated as SBR = fluorescence intensity (or chemiluminescence intensity)/background, where background is the signal intensity of the adjacent tissue acquired during imaging